The murine tumor necrosis factor-beta (lymphotoxin) gene sequence
نویسندگان
چکیده
منابع مشابه
Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines.
In this paper we show that eight of 17 tumor cell lines of various tissue origin constitutively express tumor necrosis factor (TNF) mRNA. Five of these eight cell lines concomitantly contained lymphotoxin (LT) mRNA. Of the remaining nine cell lines that lacked detectable TNF or LT gene expression, five could be induced by phorbol ester and/or cytokines to accumulate the respective mRNAs. While ...
متن کاملGene sequence of feline tumor necrosis factor alpha.
We report genomic DNA sequence of the feline tumor necrosis ACKNOWLEDGEMENT factor alpha. The gene segment was obtained by PCR (1) from _, . . ., , TT . . r _ . , , feline genomic DNA using the primers: Ttus wOrk was s u ^ r ^ by me Umversrty of Georgia Vetennary 5'-ATGAGCACTGAAAGCATGATC-3' (sense) and Medical Expenment Station. 5'-TCACAGGGCAATGATCCCAAAGTA-3' (antisense). Primers were based on ...
متن کاملGene sequence of porcine tumor necrosis factor alpha.
We report genomic DNA sequence for porcine tumor necrosis factor alpha. The gene segment was obtained by PCR (1) from porcine genomic DNA using the primers: 5' -GCGGATCCATGAGCACTGAAAGCATGATC -3 ' (sense) and 5'-GCCGAATTCAGGGCAATGATCCCAAAGT-3' (antisense). Amplification was performed in a homemade thermal cycling apparatus (2). Primers were based on published human sequence (3) from the extremes...
متن کاملTumor necrosis factor/cachectin and lymphotoxin gene expression in lymph nodes from lymphoma patients.
We investigated the mRNA content for tumor necrosis factor (TNF)/cachectin and lymphotoxin (LT) in tumoral tissues of a prospective series of 35 non-Hodgkin's (NHL) and 23 Hodgkin's (HL) lymphomas, to assess their postulated contribution to systemic symptoms. Total RNAs were extracted from diagnostic tissue specimens and submitted to Northern blot analysis, using specific TNF and LT cRNA probes...
متن کاملStructurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.
Lymphotoxin-beta receptor (LTbetaR) and CD40 are members of the tumor necrosis factor family of signaling receptors that regulate cell survival or death through activation of NF-kappaB. These receptors transmit signals through downstream adaptor proteins called tumor necrosis factor receptor-associated factors (TRAFs). In this study, the crystal structure of a region of the cytoplasmic domain o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1987
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/15.9.3937